![]() ![]() Two of the central autophagy-related proteins are Atg8 and Atg9: The amount of Atg8 determines the size of autophagosomes, whereas the Atg9 level controls the rate of autophagosome formation therefore, we are interested in the transcriptional and post-transcriptional processes that regulate their function. We have been analyzing the regulation of autophagy in Saccharomyces cerevisiae. For example, how is the initial sequestering compartment, the phagophore, nucleated? What is the origin of the membrane used for expansion of the phagophore to form the autophagosome? What are the roles of the various Atg proteins in the process of autophagosome biogenesis? Many questions concerning the molecular basis of the autophagy pathway remain unanswered. The overall pathway and the protein components of autophagy are highly conserved from yeast to human over forty autophagy-related (ATG) genes have been identified in yeast, and homologs exist for many of them in more complex eukaryotes. Designing effective therapies for these pathophysiologies will require a greater understanding of the mechanism and regulation of autophagy. ![]() Defects in autophagy in humans are associated with a wide range of pathologies including cancer, neurodegeneration, diabetes, and heart disease. The Mechanism and Regulation of Autophagyīackground: Macroautophagy/autophagy is a process of cellular self-digestion that plays a critical role in cytoprotective responses to stress. Scientific Program ISEV2018Thursday, PL 01: Plenary Session 1: Autophagy, Metabolism and AgeingChairs: Juan Falcón-Pérez Andrew Hill Location: Auditorium09:30–10:30 ![]()
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